Neu3CA

Translational Brain Research Program

About

Neu3CA is a multidisciplinary brain research program involving academic and commercial partners from both the Netherlands and Belgium. We combine technical and clinical expertise to get the most our of our research, and carry out joint projects around the theme neurocognition (more specifically neurocognitive decline). Higher brain functions such as cognition are compromised in a range of (neurodegenerative) brain disorders, including epilepsy, depression and stroke. Our research involves brain MRI, advanced simulations of brain networks, and neuromodulation.

Mission

We aim to learn more about neurocognition by studying epilepsy, the most common neurological disease, which affects 1-2% of the population. Epilepsy is characterized by epileptic seizures, but in more than half the patients also causes cognitive impairments, a.o. accelerated cognitive aging. We study the associated changes in brain organization to develop neuromodulation protocols for treatment. Also other brain conditions which affect cognition, e.g. depression and stroke, are within our scope.

Approach

Our research is typically based on MRI of the brain (anatomical/functional/diffusion weighted/spectroscopy), but may also involve EEG or MEG. We have a close collaboration between technical and clinical partners, to keep our research as relevant and aligned with clinical needs as possible. This dual approach (technical/clinical) is apparent at all levels of our team (staff, PhD candidates, students).

Neurofeedback is the concept of making someone aware of his own neuronal activity. The idea is that by making someone aware of his mental state, he may learn how to control or modify this. fMRI neurofeedback typically involves monitoring the activity in a certain region-of-interest. Within the Neu3CA program, we are developing fMRI neurofeedback for (complete) neuronal networks, with the aim of treating cognitive impairments.

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EEG (elecotro-encephalograpy) provides a direct window on neuronal activity: it captures the rapid changes in electical fields generated by neuronal firing. In this project, we combine EEG data with data-mining techniques and graph theory to find EEG-markers of neurological diseases.

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Epilepsy may have a large varierty of causes, amongst others is may develop after a stroke. Within this project, we study post-stroke epilepsy using high field (7T) MRI.

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More Projects

More Publications

René was a speaker at the SUMMA student symposium in Utrecht.

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In the March 2017 edition of the Dutch Epilepsy Foundation's Epilepsy Magazine, the launch of the Neu3CA research program was reported.

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More Posts

Bert Aldenkamp

senior investigator and founding father, KH, Maastricht UMC, TU/e, UZ Gent

Paul Boon

senior investigator and founding father, UZ Gent, U Gent, KH, TU/e

Jan Bergmans

senior investigator and founding father, TU/e, KH, Philips Research

Anton Tijhuis

senior investigator and founding father, TU/e

Kristl Vonck

senior investigator, U Gent, UZ Gent

Mykola Pechenizkiy

professor, TU/e

Evelien Carrette

clinical program director, UZ Gent, U Gent, TU/e, KH

René Besseling

technical program director, TU/e, KH, U Gent

Rob Mestrom

researcher, PhD supervisor, TU/e

Sveta Zinger

assistant professor, TU/e

Anton de Louw

researcher, PhD supervisor, KH, TU/e

Rob Rouhl

assistant professor, Maastricht UMC

Jaap Jansen

assistant professor, MUMC

Antoine Bernas

PhD candidate, TU/e

Debby Klooster

PhD candidate, TU/e, KH, UZ Gent

Elles Raaijmakers

PhD candidate, TU/e

Maarten van Rossum

PhD candidate, TU/e

Lisanne Breuer

PhD candidate, KH

Edo Grevers

PhD candidate, KH

Gerald Drenthen

PhD candidate, Maastricht UMC

Sofie Carrette

PhD candidate, UZ Gent, U Gent

Negar Ahmadi

PhD candidate, TU/e

Charlotte Germonpré

PhD candidate, U Gent

Lisanne Canjels

PhD candidate, MUMC

Stephan Heunis

PhD candidate, TU/e

Chris Baeken

affiliate, principal investigator, U Gent

Regina Luttge

affiliate, TU/e

Peter H. N. de With

affiliate, TU/e

Govert Hoogland

affiliate, Maastricht University

Wytse Wadman

affiliate, University of Amsterdam, U Gent

Robrecht Raedt

affiliate, U Gent

Marijke Miatton

affiliate, UZ Gent

Veerle de Herdt

affiliate, UZ Gent

Rolf Lamerichs

senior investigator, Philips Research

Rob Sanders

student (graduation July 2017), TU/e

All members