Cortical thickness in deteriorating patients with epilepsy


Gerald Drenthen

PhD candidate

Jaap Jansen


Bert Aldenkamp



The brain cortex contains neuronal cell bodies, at which axons (white matter fibers) end and begin, to facilitate communication with other brain regions. This basically means that a thicker cortex means more cell bodies and more white matter. If these white matter fibers project to specific other cortical regions, consequently the cortex in these connected regions in thicker as well.

This concept is employed in cortical thickness connectivity. If certain cortical regions show similar variations in thickness over subjects, they are likely to be connected.

In this project we look into specific abnormalities in cortical thickness organization in patients with cognitive deterioration and epilepsy.